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Copyright (c) 2024 MOHAMMAD FAIZ TAQIYUDDIN MOHD NOR, WAN FADZLINA WAN MUHD SHUKERI, NURUL 'AIFAA MOHD AZMI, PROFESOR DR. SHAMSUL KAMALRUJAN HASSAN
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Abstract
Although propofol is a commonly used medication for inducing general anaesthesia, it is not without side effects. In this case report, we present a patient with hepatocellular carcinoma who experienced postoperative unconsciousness following general anaesthesia induction using propofol. While this is a rare occurrence, it underscores the importance of remaining vigilant and understanding propofol’s pharmacokinetic properties. The drug can be redistributed from fat tissues into the systemic circulation, resulting in delayed recovery and potential adverse effects. We also discuss the possible impact of disease interactions, particularly hepatic impairment with possible CYP450 deficiency, on propofol metabolism. We stress the necessity of closely monitoring patients during anaesthesia induction and maintenance.
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